Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: inconsistency with their established prognostic significance

Anticancer Res. Sep-Oct 1997;17(5A):3665-9.


In this study the unexpected findings from the analysis of 278 breast cancer tissue specimens are reported. A surprising strongly positive correlation between an unfavourable and a favourable prognosis with markers cathepsin D and pS2 respectively, was revealed by linear regression analysis (Pearson, Student-T-Test). In the relevant literature reviewed only one similar, although indirect, observation was found. On the other hand, a weak relationship between pS2 and ER has emerged using the same method, while the pS2/PgR association remained strong. The latter supports the hypothesis that pS2 positivity is associated with positive PgR and may be a marker of functioning ER, irrespective of ER status. These and other similar findings underline the need for a better understanding of the underlying molecular events as well as the necessity of an effective prognostic evaluation model for breast cancer.

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / metabolism*
  • Cathepsin D / metabolism*
  • Humans
  • Immunologic Techniques
  • Lymphatic Metastasis
  • Middle Aged
  • Prognosis
  • Proteins / metabolism*
  • Receptors, Estrogen / metabolism*
  • Regression Analysis
  • Trefoil Factor-1
  • Tumor Suppressor Proteins


  • Biomarkers, Tumor
  • Proteins
  • Receptors, Estrogen
  • TFF1 protein, human
  • Trefoil Factor-1
  • Tumor Suppressor Proteins
  • Cathepsin D