Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis

J Neuroimmunol. 1997 Dec;80(1-2):172-8. doi: 10.1016/s0165-5728(97)00153-7.


Susceptibility to multiple sclerosis (MS) is associated with HLA-DRB1*1501. Many reports have suggested associations with other loci but these results remain unconfirmed. We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS). The frequency of DRB1*1501 and IL-1ra allele 2 were significantly higher in R/R MS. Association was more marked in the female sex and in patients with benign forms of R/R MS. On the other hand DR4 subtypes carrying a Val at position 86 in the DR beta chain were increased in PP MS. The present study indicates that MS is genetically heterogeneous and shows a combined effect of HLA-DR and IL-1ra genes in susceptibility to the R/R form of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Case-Control Studies
  • Disease Progression
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Male
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology*
  • Random Allocation
  • Receptors, Interleukin-1 / antagonists & inhibitors*
  • Receptors, Interleukin-1 / genetics*
  • Recurrence
  • Severity of Illness Index
  • Sex Factors
  • Sialoglycoproteins / genetics*
  • Spain / epidemiology


  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Receptors, Interleukin-1
  • Sialoglycoproteins