Genetics of sarcoidosis

Clin Chest Med. 1997 Dec;18(4):707-17. doi: 10.1016/s0272-5231(05)70414-7.


Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement. The genetics of sarcoidosis cannot be adequately addressed in small samples of patients; a large-scale study with stratification for patient phenotypic differences is necessary. A study that uses both genetic marker and environmental data would be able to control for and examine different causative mechanisms. Until such a well-designed, comprehensive study is carried out, we are left with interesting patterns of disease in families and uncertain allelic associations.

Publication types

  • Review

MeSH terms

  • Female
  • Genetic Linkage
  • HLA Antigens / genetics
  • Humans
  • Male
  • Sarcoidosis / genetics*


  • HLA Antigens