Our study with honey for its possible immunomodulatory activity reveals the immunosuppressive activity on induction of murine humoral antibody responses against different allergens as determined by passive cutaneous anaphylaxis and Ouchterlony double immunodiffusion techniques. Ovalbumin (OVA)-specific IgE antibody responses elicited with various doses were completely suppressed by different sources of commercial honeys. Honey is also found to have suppressed the induction of OVA-specific humoral antibody responses in different strains of mice. The results obtained in this work confirm the immunosuppressive activity of honey and suggest its possible applicability in conditions requiring immunosuppression.