Alveolar lipoproteinosis in lung allograft recipients

Hum Pathol. 1997 Dec;28(12):1383-6. doi: 10.1016/s0046-8177(97)90228-8.


Three cases of pulmonary alveolar proteinosis developing in lung allograft recipients are reported. In each case, repeated bouts of alveolar damage from harvest/reperfusion injury, rejection, and infection were observed before the development of intraalveolar accumulation of granular, periodic acid-Schiff-positive material in the allograft lungs. It is speculated that iatrogenic immunosuppression combined with defective clearance of alveolar material by alveolar macrophages created a milieu conducive to the accumulation of surfactant, lipoprotein, and fibrinous debris that was morphologically identical to alveolar proteinosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Eisenmenger Complex / complications
  • Eisenmenger Complex / surgery
  • Female
  • Heart Septal Defects, Atrial / complications
  • Heart Septal Defects, Atrial / surgery
  • Heart-Lung Transplantation / adverse effects
  • Heart-Lung Transplantation / pathology
  • Humans
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / surgery
  • Lung Diseases, Interstitial / complications
  • Lung Diseases, Interstitial / surgery
  • Lung Transplantation / adverse effects*
  • Lung Transplantation / pathology
  • Male
  • Middle Aged
  • Pulmonary Alveolar Proteinosis / etiology*
  • Pulmonary Alveolar Proteinosis / pathology*
  • Transplantation, Homologous