Effects of quinapril on coronary blood flow in coronary artery disease patients with endothelial dysfunction. TREND Investigators. Trial on Reversing Endothelial Dysfunction

Am J Cardiol. 1997 Dec 15;80(12):1594-7. doi: 10.1016/s0002-9149(97)00750-9.

Abstract

This pilot study evaluates the effects of quinapril, an angiotensin-converting enzyme inhibitor with high tissue-binding affinity, on microvascular endothelial function in patients with mild (<40% narrowing) coronary artery disease and epicardial endothelial dysfunction. Patients randomized to quinapril had a trend suggesting an increase in endothelium-dependent coronary blood flow response.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology
  • Adenosine / pharmacology
  • Adult
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology*
  • Blood Flow Velocity / drug effects
  • Coronary Circulation / drug effects*
  • Coronary Disease / drug therapy
  • Coronary Disease / physiopathology*
  • Endothelium, Vascular / physiopathology*
  • Female
  • Humans
  • Isoquinolines / pharmacology*
  • Male
  • Microcirculation / physiopathology
  • Middle Aged
  • Nitroglycerin / pharmacology
  • Pilot Projects
  • Quinapril
  • Tetrahydroisoquinolines*
  • Vasodilator Agents / pharmacology

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Isoquinolines
  • Tetrahydroisoquinolines
  • Vasodilator Agents
  • Nitroglycerin
  • Adenosine
  • Acetylcholine
  • Quinapril