The retinoblastoma protein pathway in cell cycle control and cancer

Exp Cell Res. 1997 Nov 25;237(1):1-6. doi: 10.1006/excr.1997.3776.

Abstract

Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinases / metabolism
  • Homeostasis
  • Humans
  • Models, Biological
  • Neoplasms / pathology*
  • Neoplasms / physiopathology*
  • Oncogenes
  • Retinoblastoma Protein / physiology*

Substances

  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases