The tumor suppressor protein p16INK4a

Exp Cell Res. 1997 Nov 25;237(1):7-13. doi: 10.1006/excr.1997.3824.


The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / physiology*
  • Cyclin-Dependent Kinases / metabolism*
  • Genes, p16
  • Humans
  • Mammals
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / pathology*
  • Neoplasms / physiopathology*
  • Proteins / genetics
  • Retinoblastoma Protein / physiology
  • Tumor Suppressor Protein p14ARF


  • Cyclin-Dependent Kinase Inhibitor p16
  • Proteins
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p14ARF
  • Cyclin-Dependent Kinases