Reaction of the aortic wall to six metallic stent materials

Acad Radiol. 1995 May;2(5):379-84. doi: 10.1016/s1076-6332(05)80338-1.


Rationale and objectives: We investigated the effects of various metallic stents on the aortic wall.

Methods: The wires of Gianturco-type expandable metallic stents were plated with gold, silver, or copper or coated with Teflon or silicone. Stents were inserted into the aortas of 15 adult mongrel dogs. The time course of radiologic, macroscopic, and histologic changes in the aorta at the site of the stent was investigated at 1, 2, and 4 weeks after implantation.

Results: The gold-plated stent appeared to produce fewer macroscopic and histopathologic changes in the aorta than the other types of stents. The neointima was thinnest with gold (83.9 +/- 40.3 microns), followed by stainless steel (103.6 +/- 57.0 microns), Teflon (115.0 +/- 30.2 microns), silicone (209.6 +/- 25.9 microns), silver (228.6 +/- 33.8 microns), and copper (unmeasurable). With the copper-plated stent, the aorta suffered severe erosion of the vessel wall, marked thrombus formation, and aortic rupture.

Conclusion: Gold is a useful intravascular material because it reacts only minimally with the vessel wall.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aorta, Abdominal / diagnostic imaging
  • Aorta, Abdominal / pathology*
  • Aortography
  • Blood Vessel Prosthesis / adverse effects*
  • Blood Vessel Prosthesis Implantation
  • Cell Division
  • Constriction, Pathologic / diagnostic imaging
  • Constriction, Pathologic / etiology
  • Constriction, Pathologic / pathology
  • Disease Models, Animal
  • Dogs
  • Metals*
  • Rupture, Spontaneous
  • Stents / adverse effects*
  • Thrombosis / diagnostic imaging
  • Thrombosis / etiology
  • Thrombosis / pathology
  • Tunica Intima / pathology*


  • Metals