Abstract
Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Adhesion / drug effects
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Carbohydrates / therapeutic use*
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Chlamydia Infections / prevention & control
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Chlamydia trachomatis
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Female
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Gonorrhea / prevention & control
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HIV Infections / prevention & control
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HeLa Cells / drug effects
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HeLa Cells / microbiology
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Herpes Simplex / prevention & control
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Humans
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Neisseria gonorrhoeae
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Sexually Transmitted Diseases, Bacterial / microbiology
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Sexually Transmitted Diseases, Bacterial / prevention & control*
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Sexually Transmitted Diseases, Viral / prevention & control*
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Sexually Transmitted Diseases, Viral / virology
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Sulfates / therapeutic use*