The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses

J Virol. 1998 Jan;72(1):415-9. doi: 10.1128/JVI.72.1.415-419.1998.

Abstract

Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / pathogenicity*
  • Amino Acid Sequence
  • Animals
  • CHO Cells
  • Cloning, Molecular
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Cricetinae
  • DNA, Complementary / genetics
  • Enterovirus / genetics
  • Enterovirus / pathogenicity*
  • Gene Expression
  • Gene Transfer Techniques
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Virus / genetics*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Tissue Distribution
  • Transfection

Substances

  • CLMP protein, human
  • CLMP protein, mouse
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • DNA, Complementary
  • RNA, Messenger
  • Receptors, Virus