Preferential localization of human CD5+ B cells in the peritoneal cavity

Scand J Immunol. 1997 Dec;46(6):541-5. doi: 10.1046/j.1365-3083.1997.d01-166.x.

Abstract

In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with non-invasive gastrointestinal tumours and found that in humans CD5+ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / immunology
  • CD5 Antigens / immunology*
  • Cell Count
  • Female
  • Humans
  • Male
  • Mice
  • Peritoneal Cavity / cytology*

Substances

  • CD5 Antigens