The impact of clinical data on interpretation of thallium scintigrams

J Nucl Cardiol. 1994 Jul-Aug;1(4):365-71. doi: 10.1007/BF02939957.


Background: The availability of clinical information often influences the interpretation of diagnostic imaging information.

Methods and results: In this study we examined the impact of such data on interpretation of exercise thallium scans and the differences in analysis of such information between radiologists and clinicians. Two hundred thirty-seven exercise tolerance test-thallium scans (122 in patients with suspected coronary disease and 115 in patients with documented coronary disease) were read prospectively, first without and then with the knowledge of clinical information. Test scores, the readers' and clinicians' interpretations of historic data, and any changes in readings or interpretation of scintigraphic data were recorded. We found that the addition of clinical information resulted in changes in interpretation of 63 test results (27%), 20 (8%) of them major. Furthermore, clinical data significantly affected final test scores in 26 patients (11%), potentially affecting clinical management in this group. The changes in test scores were triggered predominantly by differences in interpretation of perfusion abnormalities rather than thallium lung uptake or left ventricular dilation with exercise. The impact of clinical data on overall test scores was greater in patients with suspected than documented coronary disease (p < 0.05). There was good agreement in assessment of clinical information between scan readers and a clinician in tests done in patients with suspected coronary artery disease but not in patients with known coronary disease.

Conclusions: We conclude that clinical information has major influences on the interpretation of thallium scans, and interpretation of data can vary significantly between cardiologists and radiologists depending on the nature of the clinical data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coronary Disease / diagnostic imaging*
  • Exercise Test
  • Humans
  • Radionuclide Imaging
  • Thallium Radioisotopes*


  • Thallium Radioisotopes