Heparan sulphate proteoglycan and wound healing in skin

J Pathol. 1997 Nov;183(3):251-2. doi: 10.1002/(SICI)1096-9896(199711)183:3<251::AID-PATH969>3.0.CO;2-H.


Normal wound healing in skin embraces several reparative processes, many of which directly involve components of the extracellular matrix and the cutaneous basement membrane zone. Proteoglycans are a group of extracellular matrix macromolecules that have both structural and regulatory properties. In wound healing, certain proteoglycans fulfill a mechanical function of absorbing water and preventing tissue compression. However, proteoglycans may also have other roles in wound healing including a direct influence on inflammation, cell attachment and migration, and growth factor binding. Furthermore, proteoglycans may help to determine other aspects of the long-term quality of wound healing in skin through regulation of basement membrane permeability, epidermal hyperproliferation, and dermal fibrosis.

Publication types

  • Comment
  • Editorial
  • Review

MeSH terms

  • Basement Membrane / physiology
  • Heparan Sulfate Proteoglycans / physiology*
  • Humans
  • Skin / injuries*
  • Skin / physiopathology
  • Wound Healing / physiology*


  • Heparan Sulfate Proteoglycans