Signal transduction by the Wnt family of ligands
- PMID: 9425102
- PMCID: PMC1219034
- DOI: 10.1042/bj3290209
Signal transduction by the Wnt family of ligands
Abstract
The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. The loss or inappropriate activation of Wnt expression has been shown to alter cell fate, morphogenesis and mitogenesis. Recent progress has identified Wnt receptors and components of an intracellular signalling pathway that mediate Wnt-dependent transcription. This review will highlight this 'core' Wnt signal-transduction pathway, but also aims to reveal the potential diversity of Wnt signalling targets. Particular attention will be paid to the overlap between developmental biology and oncogenesis, since recent progress shows Wnt signalling forms a paradigm for an interdisciplinary approach.
Similar articles
-
New steps in the Wnt/beta-catenin signal transduction pathway.Recent Prog Horm Res. 2000;55:225-36. Recent Prog Horm Res. 2000. PMID: 11036939 Review.
-
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.Nature. 2002 Jun 6;417(6889):664-7. doi: 10.1038/nature756. Epub 2002 May 26. Nature. 2002. PMID: 12050670
-
Multiplicity of the interactions of Wnt proteins and their receptors.Cell Signal. 2007 Apr;19(4):659-71. doi: 10.1016/j.cellsig.2006.11.001. Epub 2006 Nov 16. Cell Signal. 2007. PMID: 17188462 Review.
-
Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?Endocr Rev. 2005 Dec;26(7):898-915. doi: 10.1210/er.2003-0034. Epub 2005 Aug 26. Endocr Rev. 2005. PMID: 16126938 Review.
-
The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases.Growth Factors. 2018 Apr;36(1-2):15-40. doi: 10.1080/08977194.2018.1472089. Epub 2018 May 28. Growth Factors. 2018. PMID: 29806777 Review.
Cited by
-
WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice.Discov Oncol. 2023 Jul 24;14(1):136. doi: 10.1007/s12672-023-00739-7. Discov Oncol. 2023. PMID: 37486552 Free PMC article. Review.
-
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning.Mol Med. 2023 Feb 21;29(1):26. doi: 10.1186/s10020-023-00610-z. Mol Med. 2023. PMID: 36809921 Free PMC article.
-
Modeling of Neurodegenerative Diseases: 'Step by Step' and 'Network' Organization of the Complexes of Model Systems.Int J Mol Sci. 2022 Dec 29;24(1):604. doi: 10.3390/ijms24010604. Int J Mol Sci. 2022. PMID: 36614047 Free PMC article. Review.
-
Wnt2b and Wnt5a expression is highly associated with M2 TAMs in non‑small cell lung cancer.Oncol Rep. 2022 Nov;48(5):189. doi: 10.3892/or.2022.8404. Epub 2022 Sep 14. Oncol Rep. 2022. PMID: 36102318 Free PMC article.
-
Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals.Elife. 2022 May 3;11:e77740. doi: 10.7554/eLife.77740. Elife. 2022. PMID: 35503096 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
