TOR signalling and control of cell growth

Curr Opin Cell Biol. 1997 Dec;9(6):782-7. doi: 10.1016/s0955-0674(97)80078-6.

Abstract

TOR, phosphatidylinositol 3-kinase, p70s6k, and 4E-BP1 have recently emerged as components of a major signalling pathway that is dedicated to protein translation and thus to cell growth. This pathway appears to be conserved, at least in part, in yeast, slime molds, plants, flies, and mammals. TOR and phosphatidylinositol 3-kinase control p70s6k and 4E-BP1, which, in turn, directly control the translation initiation machinery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Carrier Proteins*
  • Cell Cycle Proteins
  • Cell Division / physiology*
  • Fungal Proteins / physiology*
  • Models, Biological
  • Phosphatidylinositol 3-Kinases / physiology
  • Phosphoproteins / physiology
  • Phosphotransferases (Alcohol Group Acceptor) / physiology*
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases / physiology
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Cell Cycle Proteins
  • EIF4EBP1 protein, human
  • Fungal Proteins
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • Saccharomyces cerevisiae Proteins
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • TOR1 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases