Abstract
Currently, the favoured model for the structure of the T-cell receptor (TCR)/CD3 complex proposes a monovalent TCR alpha beta/CD3 gamma epsilon delta epsilon zeta zeta octameric complex. However, other biochemical, structural and functional data point to a bivalent (TCR alpha beta)2/CD3 gamma epsilon delta epsilon zeta zeta decameric organization, which has a favourable neutral transmembrane net charge within the complex. Here, Heinz Jacobs proposes a model for the organization of the pre-TCR and discusses its function in signal transduction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CD3 Complex / immunology
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Major Histocompatibility Complex / immunology
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Models, Chemical*
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Receptor-CD3 Complex, Antigen, T-Cell / chemistry*
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Receptor-CD3 Complex, Antigen, T-Cell / physiology
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Receptors, Antigen, T-Cell / chemistry
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell, alpha-beta / chemistry
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Signal Transduction / immunology*
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T-Lymphocytes / chemistry
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T-Lymphocytes / immunology
Substances
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CD3 Complex
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Receptor-CD3 Complex, Antigen, T-Cell
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Receptors, Antigen, T-Cell
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Receptors, Antigen, T-Cell, alpha-beta