Triple check for antigen specificity of B cells during germinal centre reactions

Immunol Today. 1997 Dec;18(12):573-7. doi: 10.1016/s0167-5699(97)01160-2.


Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells.

MeSH terms

  • Antibody Specificity*
  • Antigens / immunology*
  • B-Lymphocytes / immunology*
  • Cell Division / immunology
  • Immunoglobulin Class Switching
  • Immunologic Memory
  • Lymphocyte Activation


  • Antigens