FcRn: the MHC class I-related receptor that is more than an IgG transporter

Immunol Today. 1997 Dec;18(12):592-8. doi: 10.1016/s0167-5699(97)01172-9.


Recent data have indicated that the major histocompatibility complex (MHC) class I-related receptor FcRn plays a role in regulating serum IgG levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta suggests that the studies in rodents have relevance to understanding similar processes in humans. This has implications for the engineering of improved antibodies for therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Female
  • Histocompatibility Antigens Class I
  • Homeostasis
  • Humans
  • Immunity, Maternally-Acquired / immunology
  • Immunity, Maternally-Acquired / physiology
  • Immunoglobulin Fc Fragments / chemistry
  • Immunoglobulin G / blood
  • Immunoglobulin G / immunology*
  • Immunotherapy
  • Mice
  • Pregnancy
  • Receptors, Fc / immunology*
  • Receptors, Fc / physiology*


  • Histocompatibility Antigens Class I
  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • Receptors, Fc
  • Fc receptor, neonatal