Rubiadin, a new antioxidant from Rubia cordifolia

Indian J Biochem Biophys. 1997 Jun;34(3):302-6.

Abstract

Rubiadin, a dihydroxy anthraquinone, isolated from alcoholic extract of Rubia cordifolia, possesses potent antioxidant property. It prevents lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner. The per cent inhibition was more in the case of Fe2+ induced lipid peroxidation. The antioxidant property of the preparation has been found to be better than that of EDTA, Tris, mannitol, Vitamin E and p-benzoquinone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthraquinones / isolation & purification
  • Anthraquinones / pharmacology*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Glutathione / analysis
  • Glutathione / metabolism
  • Lipid Peroxidation / drug effects
  • Male
  • Plants, Medicinal / chemistry
  • Rats
  • Rats, Inbred Strains
  • Rubiaceae / chemistry*
  • Thiobarbituric Acid Reactive Substances / analysis

Substances

  • Anthraquinones
  • Antioxidants
  • Thiobarbituric Acid Reactive Substances
  • rubiadin
  • Glutathione