Heparin-binding EGF-like growth factor

Biochim Biophys Acta. 1997 Dec 9;1333(3):F179-99. doi: 10.1016/s0304-419x(97)00024-3.


HB-EGF is a heparin-binding member of the EGF family that was initially identified in the conditioned medium of human macrophages. Soluble mature HB-EGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HB-EGF activates two EGF receptor subtypes, HER1 and HER4 and binds to cell surface HSPG. The transmembrane form of HB-EGF is a juxtacrine growth and adhesion factor and is uniquely the receptor for diphtheria toxin. HB-EGF gene expression is highly regulated, for example by cytokines, growth factors, and transcription factors such as MyoD. HB-EGF has been implicated as a participant in a variety of normal physiological processes such as blastocyst implantation and wound healing, and in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arteriosclerosis
  • Binding Sites
  • Cell Adhesion
  • Cell Division
  • Cell Membrane / physiology
  • Chromosome Mapping
  • Epidermal Growth Factor / physiology*
  • Gene Expression Regulation
  • Genes
  • Heparan Sulfate Proteoglycans / physiology
  • Heparin / metabolism
  • Heparin-binding EGF-like Growth Factor
  • Humans
  • Hyperplasia
  • Intercellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Muscular Diseases / pathology
  • Neoplasms / physiopathology
  • Promoter Regions, Genetic
  • Protein Binding
  • Receptors, Cell Surface / physiology
  • Reproduction
  • Signal Transduction
  • Wound Healing


  • HBEGF protein, human
  • Heparan Sulfate Proteoglycans
  • Heparin-binding EGF-like Growth Factor
  • Intercellular Signaling Peptides and Proteins
  • Receptors, Cell Surface
  • Epidermal Growth Factor
  • Heparin