CD4+ T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells

Virology. 1997 Dec 8;239(1):217-25. doi: 10.1006/viro.1997.8882.


Recovery from influenza virus infection is dependent on T cell functions which can be provided either by CD8 or CD4 T cells. To identity the functions involved in recovery promoted by CD4 T cells, we have studied the course of the infection in B-cell deficient micro MT mice which had been depleted of CD8 T cells by antibody treatment. Upon infection with PR8 [A/PR/8/34(H1N1)], such B- and CD8 T cell-deficient mice mounted strong CD4 T cell responses that were comparable in size and cytokine secretion to those seen in intact mice. Yet, these B- and CD8 T cell-deficient mice could not clear the infection, in contrast to (CD8-depleted) mice containing both B- and CD4 T cells. These findings indicate that the promotion of the T-dependent antibody response is an indispensable component in the CD4 T cell-dependent recovery process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / virology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / virology
  • Immunity, Cellular*
  • Influenza A virus / immunology*
  • Lung / immunology
  • Lung / virology*
  • Mice
  • Mice, Inbred BALB C
  • Orthomyxoviridae Infections / immunology*