Sucrose as a risk factor for cancer of the colon and rectum: a case-control study in Uruguay

Int J Cancer. 1998 Jan 5;75(1):40-4. doi: 10.1002/(sici)1097-0215(19980105)75:1<40::aid-ijc7>;2-1.


In order to examine the relationship between dietary sucrose intake and colorectal cancer, a case-control study was conducted in Uruguay in the time period 1992-1996. In all, 289 cases and 564 controls, admitted for diagnosis or treatment in the 4 major hospitals in Montevideo, were considered eligible for the study. Total sucrose intake was associated with a monotonic positive gradient of risks and the odds ratio (OR) for the uppermost quartile of intake was of 2.18 (95% confidence interval, CI, 1.35-3.51). Glucose intake was associated with a small and non-significant increase in risk (OR 1.46, 95% CI 0.76-2.82). Finally, an interaction between sucrose and protein intake was found, and the OR for high intakes of sucrose and protein was 6.07.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Colonic Neoplasms / epidemiology
  • Colonic Neoplasms / etiology*
  • Dietary Sucrose / adverse effects*
  • Female
  • Glucose / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / etiology*
  • Risk Factors
  • Sex Factors
  • Socioeconomic Factors
  • Uruguay / epidemiology


  • Dietary Sucrose
  • Glucose