CD40 and its ligand in cell-mediated immunity

Agents Actions Suppl. 1998:49:17-22. doi: 10.1007/978-3-0348-8857-8_4.


CD40 and its ligand (gp39, CD40L, TBAM) is central to the control of thymus-dependent humoral immunity. However, in recent years it has become evident that CD40 signaling also is critical in the development of cell-mediated immune responses. How CD40 regulates cell-mediated immunity is discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells
  • B-Lymphocytes / immunology
  • CD40 Antigens / immunology*
  • CD40 Ligand
  • Humans
  • Immunity, Cellular*
  • Membrane Glycoproteins / immunology
  • T-Lymphocytes


  • CD40 Antigens
  • Membrane Glycoproteins
  • CD40 Ligand