Chromatin assembly factors: a dual function in nucleosome formation and mobilization?

Genes Cells. 1997 Oct;2(10):593-600. doi: 10.1046/j.1365-2443.1997.1500348.x.


Chromatin assembly is a process that interfaces DNA replication, gene expression and progression through the cell cycle, and it is therefore critically involved in many important biological phenomena. This brief review provides a general background to the study of chromatin assembly, as well as an overview of putative chromatin assembly factors. Interestingly, recent data suggest that the ATP-utilizing chromatin assembly factor, ACF, functions not only in nucleosome formation, but also in the ATP-dependent remodelling of chromatin that facilitates DNA-utilizing processes, such as transcription, replication, recombination, and repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Cell Cycle Proteins
  • Chromatin / metabolism*
  • Chromatin Assembly Factor-1
  • Chromosomal Proteins, Non-Histone*
  • DNA-Binding Proteins / metabolism
  • Histones / metabolism
  • Nuclear Proteins
  • Nucleosome Assembly Protein 1
  • Nucleosomes / metabolism
  • Proteins / metabolism
  • Transcription Factors / metabolism


  • Cell Cycle Proteins
  • Chromatin
  • Chromatin Assembly Factor-1
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Histones
  • Nuclear Proteins
  • Nucleosome Assembly Protein 1
  • Nucleosomes
  • Proteins
  • Transcription Factors
  • Adenosine Triphosphate