Abstract
Chromatin assembly is a process that interfaces DNA replication, gene expression and progression through the cell cycle, and it is therefore critically involved in many important biological phenomena. This brief review provides a general background to the study of chromatin assembly, as well as an overview of putative chromatin assembly factors. Interestingly, recent data suggest that the ATP-utilizing chromatin assembly factor, ACF, functions not only in nucleosome formation, but also in the ATP-dependent remodelling of chromatin that facilitates DNA-utilizing processes, such as transcription, replication, recombination, and repair.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine Triphosphate / metabolism
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Cell Cycle Proteins
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Chromatin / metabolism*
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Chromatin Assembly Factor-1
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Chromosomal Proteins, Non-Histone*
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DNA-Binding Proteins / metabolism
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Histones / metabolism
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Nuclear Proteins
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Nucleosome Assembly Protein 1
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Nucleosomes / metabolism
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Proteins / metabolism
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Transcription Factors / metabolism
Substances
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Cell Cycle Proteins
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Chromatin
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Chromatin Assembly Factor-1
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Histones
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Nuclear Proteins
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Nucleosome Assembly Protein 1
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Nucleosomes
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Proteins
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Transcription Factors
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Adenosine Triphosphate