The long-term effects of an accidental injection of depot corticosteroids in an infant eye

Ophthalmic Surg Lasers. 1997 Dec;28(12):1017-9.


A 4-month-old infant received an accidental intraocular injection of methylprednisolone while undergoing penetrating keratoplasty for congenital, hereditary endothelial dystrophy. This was not discovered until 4 months later, at which time the intraocular pressure (IOP) was increasing and an early cataract was forming. A lensectomy and vitrectomy were performed when the child was 12 months old. The IOP remained higher than that of the fellow eye, but the recovery was otherwise uneventful. This indicates that intraocular depot steroid may be tolerated, except when there is the occurrence of known pharmacologic side effects.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects*
  • Cataract / chemically induced*
  • Cataract Extraction
  • Corneal Dystrophies, Hereditary / surgery
  • Delayed-Action Preparations
  • Follow-Up Studies
  • Humans
  • Infant
  • Injections
  • Intraocular Pressure / drug effects
  • Keratoplasty, Penetrating
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects
  • Methylprednisolone / analogs & derivatives*
  • Methylprednisolone Acetate
  • Ocular Hypertension / chemically induced*
  • Ocular Hypertension / surgery
  • Vitrectomy


  • Anti-Inflammatory Agents
  • Delayed-Action Preparations
  • Methylprednisolone Acetate
  • Methylprednisolone