Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation

Prostaglandins Leukot Essent Fatty Acids. 1997 Oct;57(4-5):419-21. doi: 10.1016/s0952-3278(97)90421-x.


The effects of a fish-enriched diet or dietary supplements consisting of either fish oil or a docosahexaenoic acid-rich oil (DHA-oil) on platelet aggregation and hemostatic factors were studied in healthy male students. After an experimental period of 15 weeks, the levels of tissue factor pathway inhibitor, prothrombin fragment 1+2 and fibrinogen as well as factor VII activity were not changed. Factor X activity was slightly decreased by the fish diet (P < 0.05). Collagen but not ADP-induced maximum platelet aggregation decreased in the fish diet and the fish oil groups (P < 0.05 in both). In the DHA-oil group there was a slight, statistically insignificant, increase of platelet aggregation which correlated significantly with the decrease of plasma triglycerides. Platelet aggregation measured 4 h after a standardized fat meal was lower than in the fasting state and this decrease correlated with the increase of plasma triglycerides. These results show that a fish diet and fish oil, but not DHA-oil, inhibit in vitro platelet aggregation and that hemostatic factors are not affected by moderate n-3 fatty acid supplementation.

MeSH terms

  • Adolescent
  • Adult
  • Blood Coagulation Factors / drug effects*
  • Blood Coagulation Factors / metabolism
  • Diet
  • Dietary Supplements
  • Docosahexaenoic Acids / metabolism
  • Docosahexaenoic Acids / pharmacology*
  • Fish Oils / metabolism
  • Fish Oils / pharmacology*
  • Humans
  • Male
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation / physiology


  • Blood Coagulation Factors
  • Fish Oils
  • Docosahexaenoic Acids