Chronic massive knee effusion in familial Mediterranean fever

Semin Arthritis Rheum. 1997 Dec;27(3):169-72. doi: 10.1016/s0049-0172(97)80016-9.


Objective: To document the occurrence of chronic massive knee effusions in patients with familial Mediterranean fever (FMF).

Patients: Three cases of chronic massive knee effusion of young FMF patients requiring open synovectomy are presented.

Results: Open synovectomy necessitated protracted rehabilitation, eventually with good results.

Conclusions: FMF should be considered in the differential diagnosis of chronic massive knee effusion. Early diagnosis and daily colchicine treatment generally result in a good clinical outcome and may eliminate the need for open synovectomy in favor of arthroscopic surgery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthrography
  • Chronic Disease
  • Familial Mediterranean Fever / complications*
  • Female
  • Humans
  • Hypertrophy
  • Knee Joint* / diagnostic imaging
  • Knee Joint* / metabolism
  • Knee Joint* / pathology
  • Male
  • Osteoarthritis / diagnostic imaging
  • Osteoarthritis / etiology*
  • Osteoarthritis / pathology
  • Synovial Fluid / metabolism*
  • Synovial Membrane / metabolism
  • Synovial Membrane / pathology