The cyclin box fold: protein recognition in cell-cycle and transcription control

Trends Biochem Sci. 1997 Dec;22(12):482-7. doi: 10.1016/s0968-0004(97)01144-4.


Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Cell Cycle
  • Cyclin A / chemistry*
  • Cyclin A / metabolism
  • Cyclin H
  • Cyclins / chemistry*
  • Cyclins / metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Retinoblastoma Protein / chemistry*
  • Retinoblastoma Protein / metabolism
  • Sequence Homology, Amino Acid
  • Transcription Factor TFIIB
  • Transcription Factors / chemistry*
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Cyclin A
  • Cyclin H
  • Cyclins
  • Retinoblastoma Protein
  • Transcription Factor TFIIB
  • Transcription Factors