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Review
. 1997 Dec;22(12):482-7.
doi: 10.1016/s0968-0004(97)01144-4.

The Cyclin Box Fold: Protein Recognition in Cell-Cycle and Transcription Control

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Review

The Cyclin Box Fold: Protein Recognition in Cell-Cycle and Transcription Control

M E Noble et al. Trends Biochem Sci. .

Abstract

Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.

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