Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder

Genet Epidemiol. 1997;14(6):675-80. doi: 10.1002/(SICI)1098-2272(1997)14:6<675::AID-GEPI21>3.0.CO;2-M.


We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age-dependent penetrance functions that best fit the data and that allow for residual familial correlations. Specifically, we introduce here a simple method to allow for a sibling correlations. that is not due to segregation at the linked locus, and then extend the results of Stine et al. [1995] by using the best fitting "regressive" model of this kind as input into a lod score linkage analysis. Although a formal segregation analysis was not attempted, a surprising finding was that, except for doubtful linkage to D18S41, there is little evidence for genetic transmission of bipolar disorder in these families.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Bipolar Disorder / genetics*
  • Chromosomes, Human, Pair 18
  • Female
  • Genetic Linkage*
  • Humans
  • Likelihood Functions
  • Lod Score
  • Logistic Models
  • Male
  • Models, Genetic*
  • Models, Statistical*
  • Nuclear Family*
  • Regression Analysis