MCMC segregation and linkage analysis

Genet Epidemiol. 1997;14(6):1011-6. doi: 10.1002/(SICI)1098-2272(1997)14:6<1011::AID-GEPI75>3.0.CO;2-L.


Our objective was to infer the genetic model for the quantitative traits using a variety of methods developed in our group. Only a single data set was analyzed in any one analysis, although some comparison between data sets was made. In addition, the simulated model was not known during the course of the analysis. Basic modeling and segregation analyses for the five quantitative traits was followed by several simple genome scans to indicate areas of interest. A Markov chain Monte Carlo (MCMC) multipoint quantitative trait locus (QTL) mapping approach was then used to estimate the posterior probabilities of linkage of QTL to each chromosome simultaneously with trait model parameters, and to further localize the genes. Comparisons between the nuclear family and pedigree data sets indicated a greater power for QTL detection and mapping with the pedigree data sets. Even with the pedigree data, however, precise localization of the QTL did not appear to be possible using single replicate data sets. Two of the three genes with effects on trait Q1 were detected by the MCMC method.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Computer Simulation*
  • Female
  • Genetic Linkage*
  • Humans
  • Likelihood Functions
  • Logistic Models
  • Male
  • Meiosis / genetics*
  • Models, Genetic*
  • Monte Carlo Method
  • Nuclear Family
  • Probability
  • Quantitative Trait, Heritable*