Affected sib-pair tests for linkage: type I errors with dependent sib-pairs

Genet Epidemiol. 1997;14(6):1107-11. doi: 10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K.


We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) information appears robust. Missing parental marker data leads to a decrease of type I errors in all cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Analysis of Variance
  • Female
  • Genetic Diseases, Inborn / genetics*
  • Genetic Linkage*
  • Genetic Markers
  • Genotype
  • Heterozygote
  • Humans
  • Male
  • Matched-Pair Analysis
  • Monte Carlo Method
  • Nuclear Family*
  • Predictive Value of Tests


  • Genetic Markers