Abstract
We measured the plasma levels of anti-inflammatory cytokines, including interleukin 1 receptor antagonist (IL-1ra), IL-4 and IL-10; inflammatory cytokines, including IL-2, IL-6, IL-8 and tumor necrosis factor receptor I and II (TNFR I and TNFR II); and endotoxin in 11 patients with septic shock associated with gram-negative bacteria and 12 patients with sepsis not associated with shock. The plasma levels of IL-1ra and IL-10 were elevated in the septic shock group compared with the sepsis group. TNFR I and TNFR II levels tend to be higher in the septic shock group. The plasma level of TRNF-alpha was significantly correlated with levels of IL-1ra, IL-4, IL-10, TNFR I, and TNFR II. The elevated levels of the anti-inflammatory cytokines, TNFR I, and TNFR II, appeared to reflect an attempt to suppress the shock syndrome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antigens, CD / blood
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Cytokines / blood*
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-10 / blood
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Interleukin-2 / blood
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Interleukin-4 / blood
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Interleukin-6 / blood
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Interleukin-8 / blood
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Male
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Middle Aged
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Receptors, Tumor Necrosis Factor / blood
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Sepsis / blood*
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Sepsis / pathology
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Shock, Septic / blood*
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Shock, Septic / pathology
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Sialoglycoproteins / blood
Substances
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Antigens, CD
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Cytokines
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-2
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Interleukin-6
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Interleukin-8
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Receptors, Tumor Necrosis Factor, Type II
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Sialoglycoproteins
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Interleukin-10
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Interleukin-4