Chromosomal aberrations in a consecutive series of childhood rhabdomyosarcoma

Med Pediatr Oncol. 1998 Mar;30(3):156-9. doi: 10.1002/(sici)1096-911x(199803)30:3<156::aid-mpo5>;2-g.


Background and procedure: During a 13-year period, 22 children were treated for rhabdomyosarcoma (RMS). In 18 of these patients chromosome analysis was attempted on material from tumor biopsies, fine needle aspiration biopsies and/or bone marrow samples.

Results: Clonal chromosome aberrations were detected in 14 cases; 7 of 9 embryonal RMS, 6 of 8 alveolar RMS and in the single case of pleomorphic RMS cytogenetic failures were more frequent in fine needle aspiration biopsies than in tumor biopsies. The characteristic t(2;13) translocation was seen in 2 alveolar RMS but not in any of the other subtypes. In 3 of the embryonal RMS hyperdiploid or hypertetraploid karyotypes with few or no structural rearrangements were seen. In all 3 cases the clinical course was relatively benign, suggesting that certain karyotypic patterns in RMS may be of prognostic significance.

Conclusions: Our results add to the evidence that cytogenetic analysis should be an integral part of the diagnostic examinations of children with RMS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chromosome Aberrations / genetics*
  • Female
  • Humans
  • Infant
  • Karyotyping
  • Male
  • Rhabdomyosarcoma / genetics*