Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 284 (1), 151-61

Dopamine Release in the Nucleus Accumbens During Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An in Vivo Fast-Cyclic Voltammetry Study

Affiliations
  • PMID: 9435173

Dopamine Release in the Nucleus Accumbens During Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An in Vivo Fast-Cyclic Voltammetry Study

Z X Xi et al. J Pharmacol Exp Ther.

Abstract

Mu and kappa opioid agonists are known to produce different, and sometimes opposite, effects on several pharmacological and behavioral measures. However, whether kappa agonists can be used to antagonize the reinforcing and putative dopamine (DA)-releasing properties of a mu agonist such as heroin is unclear. With the use of the high temporal and spatial resolution of in vivo fast-cyclic voltammetry to measure changes in extracellular DA in the nucleus accumbens (NAcc), we observed (1) dose-dependent increases in DA in the NAcc during heroin self-administration (SA), (2) that coadministration of the kappa agonist U50,488H with heroin or intracerebroventricular dynorphin A pretreatment significantly depressed the heroin-stimulated DA release during SA, where U50,488H alone inhibited the basal DA release in the NAcc, (3) that coadministration of low-dose U50,488H or dynorphin A significantly increased heroin SA behavior, whereas high-dose U50,488H, which alone did not support SA behavior, reduced or completely blocked heroin SA and (4) that nor-binaltorphimine dihydrochloride (a selective kappa receptor antagonist) potentiated DA release in the NAcc and modestly decreased heroin SA. Taken together, these data suggest that endogenous kappa receptor activation can inhibit mu agonist-induced activation of the mesolimbic DA pathway, which may in turn depress heroin-induced reinforcement.

Similar articles

See all similar articles

Cited by 26 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback