Hypercalcemia and alkalosis due to the milk-alkali syndrome: a case report and review

Yale J Biol Med. Nov-Dec 1996;69(6):517-23.


At one time, when antacids were the primary medical means of treating peptic ulcer disease, the milk-alkali syndrome was not an uncommon cause of hypercalcemia. The simultaneous occurrence of hypercalcemia, alkalosis, and renal failure, in conjunction with the appropriate history of ingestion fof antacids, was suggestive of the syndrome. With the advent of antisecretory therapy, however, the milk-alkali syndrome has become an uncommon diagnosis. I report a case of milk-alkali syndrome and review the history of this syndrome as reported in the medical literature. Contemporary reports have focused on understanding the pathophysiology of the syndrome. Recent series have identified a shifting demographic profile, as increasing numbers of elderly women consume calcium carbonate as an anti-osteoporosis measure.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Alkalosis*
  • Female
  • Humans
  • Hypercalcemia*
  • Male