Ten-year follow-up of helium ion therapy for uveal melanoma

Am J Ophthalmol. 1998 Jan;125(1):81-9. doi: 10.1016/s0002-9394(99)80238-4.


Purpose: To examine the results of helium ion irradiation in 218 patients with uveal melanoma treated more than 10 years ago.

Method: A retrospective review was made of 218 patients (218 eyes) treated with helium ion radiation for uveal melanoma between 1978 and 1984.

Results: After helium ion irradiation, 208 (95.4%) of 218 eyes had local tumor control. Ten years after irradiation, 46 (22.4%) of 218 eyes had been enucleated; the majority of enucleations (37 of 46) resulted from anterior ocular segment complications. Ten years after radiation, 102 (46.8%) of the 218 patients were dead; 51 had non-melanoma-related deaths and 51 had died of metastatic melanoma. Best-corrected visual acuity after radiation was greater than 20/40 in 21 (23%) of 93 eyes of the patients who were alive and who had retained their eyes 10 or more years after treatment. In patients with tumors less than 6 mm in height and more than 3 mm distant from the nerve or the fovea, 13 (72%) of 18 retained visual acuity greater than 20/40. In contrast, only 11% of the patients with either thicker tumors or those close to the nerve or fovea retained that level of visual acuity.

Conclusions: Helium ion irradiation of uveal melanoma is associated with good local tumor control and reasonable retention of the treated eye 10 years after treatment. In eyes with tumors less than 6 mm in thickness and more than 3 mm distant from the optic nerve and fovea, many retain excellent vision.

MeSH terms

  • Adult
  • Aged
  • Dose Fractionation, Radiation
  • Eye Enucleation
  • Female
  • Follow-Up Studies
  • Helium*
  • Humans
  • Male
  • Melanoma / mortality
  • Melanoma / physiopathology
  • Melanoma / radiotherapy*
  • Middle Aged
  • Prognosis
  • Radiotherapy, High-Energy*
  • Retrospective Studies
  • Survival Rate
  • Uveal Neoplasms / mortality
  • Uveal Neoplasms / physiopathology
  • Uveal Neoplasms / radiotherapy*
  • Visual Acuity / physiology


  • Helium