Interferon treatment for corneolimbal squamous dysplasia

Am J Ophthalmol. 1998 Jan;125(1):118-9. doi: 10.1016/s0002-9394(99)80252-9.


Purpose: To report a patient with corneolimbal squamous dysplasia successfully treated with interferon therapy.

Methods: A 78-year-old man had a gelatinous and vascularized lesion involving the left cornea and adjacent limbus. Impression cytology studied with periodic acid--Schiff-hematoxylin stain disclosed severe squamous dysplasia. Topical instillation and subconjunctival injection of interferon alpha-2b was instituted.

Results: The gelatinous tumor mass involving the cornea and adjacent limbus completely resolved 2 months after interferon treatment. He showed no sign of recurrence during the 10-month follow-up.

Conclusion: Interferon therapy may be a therapeutic alternative for treating corneolimbal squamous dysplasia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / therapy*
  • Corneal Diseases / pathology
  • Corneal Diseases / therapy*
  • Eye Neoplasms / pathology
  • Eye Neoplasms / therapy*
  • Humans
  • Injections
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use*
  • Limbus Corneae
  • Male
  • Ophthalmic Solutions
  • Recombinant Proteins
  • Treatment Outcome


  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Ophthalmic Solutions
  • Recombinant Proteins