Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet

Peptides. 1998;19(1):157-65. doi: 10.1016/s0196-9781(97)00258-1.


We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas Ov rats showed a significant increase in GAL mRNA levels. None of these changes was present in rats overfed for 6.5 months. These differential changes in hypothalamic GAL and NPY transmissions may contribute to the different susceptibility of the two rat subpopulations to the weight-promoting effects of the hypercaloric diet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arcuate Nucleus of Hypothalamus / chemistry*
  • Blood Glucose / analysis
  • Body Weight
  • Diet
  • Eating
  • Fatty Acids / blood
  • Galanin / analysis*
  • Galanin / metabolism
  • Hyperphagia*
  • Immunohistochemistry
  • In Situ Hybridization
  • Insulin / blood
  • Male
  • Neuropeptide Y / analysis*
  • Neuropeptide Y / metabolism
  • Obesity / metabolism*
  • Oligodeoxyribonucleotides / chemistry
  • Paraventricular Hypothalamic Nucleus / chemistry*
  • RNA, Messenger / analysis
  • Rats
  • Rats, Sprague-Dawley


  • Blood Glucose
  • Fatty Acids
  • Insulin
  • Neuropeptide Y
  • Oligodeoxyribonucleotides
  • RNA, Messenger
  • Galanin