Hypogammaglobulinemia and anemia 18 years after thymoma resection

J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):846-8. doi: 10.1016/s0091-6749(97)70283-5.


Immunodeficiency with a thymoma (Good's syndrome) is a rare condition occurring in 7% to 13% of patients with adult-onset hypogammaglobulinemia. In 80% of cases, hypogammaglobulinemia is detected within 5 years of the identification of the thymoma. A 70-year-old man was found to have hypogammaglobulinemia 18 years after a thymoma had been resected. Cellular immunophenotyping revealed there were no detectable B cells, decreased CD4+ cells, and increased CD8+ cells. Both CD4+ and CD8+ subsets expressed increased populations of CD38+ DR+ cells and CD45RO+ cells. The CD8+ CD28+ population was markedly reduced. Inducible cytokine production by the patient's peripheral blood mononuclear cells revealed decreased IL-2, IL-10, and interferon-gamma production. These data suggest that patients with Good's syndrome have activated memory T cells that have dysregulated cytokine production.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / etiology*
  • Agammaglobulinemia / immunology
  • Anemia / etiology*
  • Anemia / immunology
  • Cytokines / biosynthesis
  • Humans
  • Immunophenotyping
  • Male
  • Mediastinal Neoplasms / immunology
  • Mediastinal Neoplasms / surgery*
  • Middle Aged
  • Syndrome
  • T-Lymphocyte Subsets / classification
  • T-Lymphocyte Subsets / metabolism
  • Thymoma / immunology
  • Thymoma / surgery*


  • Cytokines