Efficacy of a dry fibrin sealant dressing for hemorrhage control after ballistic injury

Arch Surg. 1998 Jan;133(1):32-5. doi: 10.1001/archsurg.133.1.32.


Objective: To determine if a dry fibrin sealant dressing (DFSD) will provide superior hemostasis when compared with regular gauze in a ballistic injury animal model.

Design: A nonsurvival randomized goat study.

Setting: A federal biomedical research institute.

Subjects: Eighteen anesthetized Angora goats.

Interventions: Uncontrolled hemorrhage was induced by a complex ballistic extremity injury. Control of hemorrhage was achieved by applying and holding pressure with the DFSD or regular gauze for 2 minutes. The dressings were left in place for 1 hour.

Main outcome measures: Total blood loss, mean arterial pressure, ballistic injury, and mortality were recorded after 1 hour.

Results: The injuries were equivalent for the 2 groups. No animal mortality was seen. After 1 hour, the mean (+/-SEM) blood loss was 124+/-64 mL in the DFSD-treated group and 377+/-64 mL in the gauze dressings-treated group (P=.01). Twenty minutes after injury, the mean arterial pressure was 95.0 mm Hg (+/-SEM, +/-4.7 mm Hg) in the DFSD-treated group and 70.0+/-5.0 mm Hg in the gauze dressings-treated group. The difference persisted for the remainder of the study (P=.01).

Conclusion: The DFSD was superior to gauze in decreasing blood loss and maintaining blood pressure while retaining the simplicity of standard dressing application.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Fibrin Tissue Adhesive / therapeutic use*
  • Goats
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Occlusive Dressings
  • Pressure
  • Wounds, Gunshot / complications
  • Wounds, Gunshot / therapy*


  • Fibrin Tissue Adhesive