Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C

Am J Ophthalmol. 1997 Sep;124(3):397-9. doi: 10.1016/s0002-9394(14)70834-7.


Purpose: To study the effect of topical mitomycin C on conjunctival squamous neoplasia.

Methods: Three patients with recurrent conjunctival epithelial neoplasia were treated with topical mitomycin C 0.04%.

Results: Six to 9 months after treatment, no patient had clinical evidence of tumor recurrence. Conjunctival biopsy in two patients and cytology in one patient showed no evidence of tumor 1 to 4 months after treatment. One patient required short-term treatment for corneal edema and epithelial toxicity.

Conclusion: Topical mitomycin C caused tumor regression without recurrence for 6 to 9 months after treatment.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Aged
  • Aged, 80 and over
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / therapeutic use*
  • Carcinoma in Situ / drug therapy*
  • Carcinoma in Situ / pathology
  • Conjunctival Neoplasms / drug therapy*
  • Conjunctival Neoplasms / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage
  • Mitomycin / therapeutic use*
  • Ophthalmic Solutions
  • Recurrence
  • Remission Induction


  • Antibiotics, Antineoplastic
  • Ophthalmic Solutions
  • Mitomycin