Iatrogenic central retinal vein occlusion and hyperviscosity associated with high-dose intravenous immunoglobulin administration

Am J Ophthalmol. 1997 Sep;124(3):416-8. doi: 10.1016/s0002-9394(14)70844-x.

Abstract

Purpose: To describe a patient with iatrogenically induced central retinal vein occlusions secondary to serum hyperviscosity from intravenous immunoglobulin administration.

Method: Case report.

Results: The patient developed bilateral central retinal vein occlusions in association with high-dose intravenous immunoglobulins. The central retinal vein occlusions resolved when the immunoglobulins were withheld and serum hyperviscosity decreased.

Conclusion: Administration of high-dose intravenous immunoglobulins can be associated with hyperviscosity syndrome manifested by central retinal vein occlusion.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Antiviral Agents / therapeutic use
  • Blood Viscosity*
  • Cytomegalovirus Infections / therapy
  • Fundus Oculi
  • Humans
  • Iatrogenic Disease
  • Immunoglobulins, Intravenous / administration & dosage
  • Immunoglobulins, Intravenous / adverse effects*
  • Male
  • Pneumonia, Viral / therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Retinal Vein Occlusion / blood*
  • Retinal Vein Occlusion / etiology*
  • Retinal Vein Occlusion / physiopathology
  • Syndrome

Substances

  • Antiviral Agents
  • Immunoglobulins, Intravenous