Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilator circuits: an in vitro study

Chest. 1998 Jan;113(1):186-91. doi: 10.1378/chest.113.1.186.


Study objectives: The aim of our study was to determine the in vitro delivery of salbutamol from a pressurized metered-dose inhaler (pMDI) containing hydrofluoroalkane (HFA) propellant through various delivery devices to four models of a pediatric lung.

Design: To determine the effect of electrostatic charge, delivery of salbutamol was initially assessed with a multistage liquid impinger (MSLI) through an inline nonchamber device (Baxter MDI Adapter) and a small (Aerochamber MV) and a large (Nebuhaler) inline chamber device. Following this, the delivery was assessed to four lung models appropriate for a child of 70 kg, 50 kg, 15 kg, and 4 kg, with the same three reduced static devices inserted directly into a pediatric ventilator circuit.

Measurements and results: Reduction of electrostatic charge improved small particle delivery through holding chambers to the MSLI by 12 to 14%. In the ventilator model, the mean delivery was between 1.9% and 5.4% for the nonchamber device, between 14.3% and 27.2% for the small holding chamber, and between 7.2% and 25.7% for the large holding chamber. Delivery was the least efficient in the 4-kg model compared to the 70-kg, 50-kg, and 15-kg models.

Conclusions: Salbutamol from an HFA pMDI is delivered efficiently through inline holding chambers with reduced static in pediatric ventilator settings. A large holding chamber has no advantage over a small holding chamber. In addition, salbutamol delivery is more efficient through a holding chamber than through a nonchamber device.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Inhalation
  • Aerosol Propellants / administration & dosage*
  • Albuterol / administration & dosage*
  • Bronchodilator Agents / administration & dosage*
  • Child
  • Drug Delivery Systems
  • Humans
  • Hydrocarbons, Fluorinated*
  • Lung / drug effects
  • Models, Anatomic
  • Nebulizers and Vaporizers*
  • Respiration, Artificial / methods
  • Static Electricity


  • Aerosol Propellants
  • Bronchodilator Agents
  • Hydrocarbons, Fluorinated
  • Albuterol