Inhibition of naloxone-induced withdrawal in morphine dependent mice by 1-trans-delta9-tetrahydrocannabinol

Eur J Pharmacol. 1976 Mar;36(1):259-62. doi: 10.1016/0014-2999(76)90283-1.


The effects of various doses of 1-trans-delta9-tetrahydrocannabinol (delta9-THC) on naloxone-induced withdrawal were studied in mice rendered dependent on morphine by the pellet implantation procedure. When administered i.p., 30 min prior to naloxone, delta9-THC, inhibited the naloxone-induced withdrawal jumping response. Two other signs of morphine withdrawal (defecation and rearing behavior) were also suppressed by deltapTHC. It is suggested that delta9-THC or some of its derivatives may have potential use in narcotic detoxification.

MeSH terms

  • Animals
  • Cannabis / pharmacology*
  • Dose-Response Relationship, Drug
  • Dronabinol / administration & dosage
  • Dronabinol / pharmacology*
  • Humans
  • Male
  • Mice
  • Morphine Dependence*
  • Naloxone / antagonists & inhibitors*
  • Substance Withdrawal Syndrome / chemically induced


  • Naloxone
  • Dronabinol