The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization

Genomics. 1997 Dec 15;46(3):435-42. doi: 10.1006/geno.1997.5065.


We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • DNA, Complementary
  • Forkhead Box Protein M1
  • Forkhead Transcription Factors
  • Humans
  • Mice
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • Sequence Homology, Amino Acid
  • Transcription Factors / genetics*


  • DNA, Complementary
  • FOXM1 protein, human
  • Forkhead Box Protein M1
  • Forkhead Transcription Factors
  • Foxm1 protein, mouse
  • Foxm1 protein, rat
  • Transcription Factors

Associated data

  • GENBANK/Y12773