An evaluation of prognostic factors in uterine carcinosarcoma

Gynecol Oncol. 1997 Dec;67(3):316-21. doi: 10.1006/gyno.1997.4875.


The traditional clinical and histopathological prognostic variables and DNA ploidy were analyzed in 46 patients with histologically verified uterine carcinosarcoma. Twenty-three tumors were of the homologous and 23 of the heterologous type. Evaluable flow cytometric DNA histograms from paraffin-embedded tumor tissue were obtained in 39 patients. The overall 5-year cancer related survival was 31%. All tumors were of high malignancy grade. In univariate analysis of survival, extrauterine spread of tumor (P = 0.007), age (P = 0.008), and tumor diameter (P = 0.04) obtained statistical significance. Tumors with components of serous or clear cell carcinomas had a less favorable prognosis (P = 0.017). There was no difference in survival between patients with homologous and heterologous tumors (P = 0.39). Mitotic count, vessel invasion, and DNA ploidy did not obtain prognostic significance. In Cox multivariate analysis, extrauterine spread of tumor (P = 0.004) and age (P = 0.004) were found to be the most important prognostic factors followed by content of serous or clear cell carcinoma components (P = 0.027).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinosarcoma / diagnosis*
  • Carcinosarcoma / pathology
  • DNA, Neoplasm / genetics
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Mitotic Index
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Parity
  • Ploidies
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Survival Analysis
  • Uterine Neoplasms / diagnosis*
  • Uterine Neoplasms / pathology


  • DNA, Neoplasm