Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice

Curr Opin Nephrol Hypertens. 1998 Jan;7(1):21-6. doi: 10.1097/00041552-199801000-00004.


Analyses of platelet-derived growth factor (PDGF) and PDGF-receptor knockout mice show that the development of specific subsets of smooth muscle cells (SMCs) depend on PDGF. Pericytes and mesangial cells failed to develop in PDGF-B deficient embryos, whereas alveolar SMCs failed to develop in PDGF-A deficient embryos. The ontogeny of pericytes and alveolar SMCs suggests a common theme in the formation of PDGF-dependent SMCs, in which PDGF-receptor positive SMC progenitors spread from proximal to distal sites along PDGF-expressing epithelial, or endothelial, tubes.

Publication types

  • Review

MeSH terms

  • Animals
  • Fibroblasts / physiology
  • Gene Targeting
  • Humans
  • Mice
  • Mice, Knockout
  • Platelet-Derived Growth Factor / metabolism
  • Platelet-Derived Growth Factor / physiology*
  • Receptors, Platelet-Derived Growth Factor / genetics*
  • Receptors, Platelet-Derived Growth Factor / physiology*


  • Platelet-Derived Growth Factor
  • platelet-derived growth factor A
  • Receptors, Platelet-Derived Growth Factor